Posted on 25 มีนาคม 2024
Technology Overview
Triterpene alcohols and phytosterols, both classified assteroid alcohols, have applications in a wide range of products, including dietary supplements, functional foods, and cosmetics. Both compounds offer numerous health benefits, such as lowering LDL cholesterol, reducing fat absorption, anti-inflammatory properties, and antioxidant effects.
Gamma-oryzanol, abundantly present in rice bran oil, is a mixture of ferulic acid esters of triterpene alcohols and phytosterols and therefore represents a vital source for the extraction of triterpene alcohols and phytosterols. The manufacturing process typically involves the hydrolysis of gamma-oryzanol and purification of triterpene alcohols and phytosterols. Traditional purification methods have various drawbacks, including complexity, time consumption, the use of toxic organic solvents, and temperature variability.
Key Features & Benefits
This process represents a simple production for triterpene alcohols and phytosterols from gamma-oryzanol. The first step is an alkaline hydrolysis of crude gamma-oryzanol ina heated alcohol solution, followed by precipitation using a water-miscible antisolvent. The process has been streamlined to reduce the complexity of purifying triterpene alcohols and phytosterols, achieving a purity level of 95-99% and a theoretical yield of 90%. These purifiedcompounds can be incorporated into various products. In addition, the process yields ferulic acid as a valuable by-product, which possesses antioxidant properties and can be utilized in a multitude of applications.
Researcher(s)
Assoc. Prof. Dr. Kornkanok Aryusuk
Mr. Akkaradech Nakornsadet
Mr. Apiwat Jiruttisakul
Ms. Siriluck Pojjamapornpun
Ms. Piraporn Sombutsuwan
Biochemical Technology Department, School of Bioresources and Technology
IP Status
Petty Patent No. 2203000192
Contact
Intellectual Properties and Technology Transfer Section
Research, Innovation and Partnerships Office (RIPO)
Tel: 02-470-9626
Email: tto@kmutt.ac.th